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多天的经颅直流电刺激引起肌张力障碍儿童临床微不足道的变化 一项试点研究

作者:刘爽 编译 来源:医学论坛网 日期:2016-01-17
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Multiday Transcranial Direct Current Stimulation Causes Clinically Insignificant Changes in Childhood Dystonia
A Pilot Study
Nasir H. Bhanpuri, Matteo Bertucco, Scott J. Young, Annie A. Lee,Terence D. Sanger
Abstract
Abnormal motor cortex activity is common in dystonia. Cathodal transcranial direct current stimulation may alter cortical activity by decreasing excitability while anodal stimulation may increase motor learning. Previous results showed that a single session of cathodal transcranial direct current stimulation can improve symptoms in childhood dystonia. Here we performed a 5-day, sham-controlled, double-blind, crossover study, where we measured tracking and muscle overflow in a myocontrol-based task. We applied cathodal and anodal transcranial direct current stimulation (2 mA, 9 minutes per day). For cathodal transcranial direct current stimulation (7 participants), 3 subjects showed improvements whereas 2 showed worsening in overflow or tracking error. The effect size was small (about 1% of maximum voluntary contraction) and not clinically meaningful. For anodal transcranial direct current stimulation (6 participants), none showed improvement, whereas 5 showed worsening. Thus, multiday cathodal transcranial direct current stimulation reduced symptoms in some children but not to a clinically meaningful extent, whereas anodal transcranial direct current stimulation worsened symptoms. Our results do not support transcranial direct current stimulation as clinically viable for treating childhood dystonia.
doi:10.1177/0883073815575369
J Child Neurol October 2015vol. 30 no. 12 1604-1615

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